DNA-based data storage systems have the potential to offer unprecedented increases in density and longevity over conventional storage mediums. Starting from the assumption that advances in synthesis and sequencing technology will soon make DNA-based storage cost competitive with conventional media, we will need ways of organizing, accessing, and manipulating the data stored in DNA to harness its full potential. There are a range of possible storage system designs. This talk will cover three systems that the speaker co-developed and prototyped at NC State / DNAli Data Technologies.